Differential effects of alpha-particle radiation and x-irradiation on genes associated with apoptosis.
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ABSTRACT:
SUBMITTER: Chauhan V
PROVIDER: S-EPMC3199915 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Publications
Differential effects of alpha-particle radiation and x-irradiation on genes associated with apoptosis.
Chauhan Vinita V Howland Matthew M Chen Jeremy J Kutzner Barbara B Wilkins Ruth C RC
Radiology research and practice 20110609
This study examined differential effects of alpha-(α-) particle radiation and X-rays on apoptosis and associated changes in gene expression. Human monocytic cells were exposed to α-particle radiation and X-rays from 0 to 1.5 Gy. Four days postexposure, cell death was measured by flow cytometry and 84 genes related to apoptosis were analyzed using real-time PCR. On average, 33% of the cells were apoptotic at 1.5 Gy of α-particle radiation. Transcript profiling showed statistical expression of 15 ...[more]
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