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BRCA1 is required for postreplication repair after UV-induced DNA damage.

ABSTRACT: BRCA1 contributes to the response to UV irradiation. Utilizing its BRCT motifs, it is recruited during S/G2 to UV-damaged sites in a DNA replication-dependent but nucleotide excision repair (NER)-independent manner. More specifically, at UV-stalled replication forks, it promotes photoproduct excision, suppression of translesion synthesis, and the localization and activation of replication factor C complex (RFC) subunits. The last function, in turn, triggers post-UV checkpoint activation and postreplicative repair. These BRCA1 functions differ from those required for DSBR.

SUBMITTER: Pathania S

PROVIDER: S-EPMC3200447 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature

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BRCA1 is required for postreplication repair after UV-induced DNA damage.

Pathania Shailja S Nguyen Jenna J Hill Sarah J SJ Scully Ralph R Adelmant Guillaume O GO Marto Jarrod A JA Feunteun Jean J Livingston David M DM

Molecular cell 20110929 2

BRCA1 contributes to the response to UV irradiation. Utilizing its BRCT motifs, it is recruited during S/G2 to UV-damaged sites in a DNA replication-dependent but nucleotide excision repair (NER)-independent manner. More specifically, at UV-stalled replication forks, it promotes photoproduct excision, suppression of translesion synthesis, and the localization and activation of replication factor C complex (RFC) subunits. The last function, in turn, triggers post-UV checkpoint activation and post ...[more]

PMID: 21963239

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