Ontology highlight
ABSTRACT:
SUBMITTER: Zheng D
PROVIDER: S-EPMC3200529 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Zheng Dan D Seferos Dwight S DS Giljohann David A DA Patel Pinal C PC Mirkin Chad A CA
Nano letters 20090901 9
We demonstrate a composite nanomaterial, termed an aptamer nano-flare, that can directly quantify an intracellular analyte in a living cell. Aptamer nano-flares consist of a gold nanoparticle core functionalized with a dense monolayer of nucleic acid aptamers with a high affinity for adenosine triphosphate (ATP). The probes bind selectively to target molecules and release fluorescent reporters which indicate the presence of the analyte. Additionally, these nanoconjugates are readily taken up by ...[more]