Ontology highlight
ABSTRACT:
SUBMITTER: Do JS
PROVIDER: S-EPMC3200541 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Journal of immunology (Baltimore, Md. : 1950) 20110314 8
Th 17 cells have been implicated in the pathogenesis of colitis; however, a cellular mechanism by which colitogenic Th17 immunity arises in vivo remains unclear. In this study, we report that a subset of IL-17(+) γδ T cells plays a crucial role in enhancing in vivo Th17 differentiation and T cell-mediated colitis. TCRβ(-/-) mice were highly susceptible to T cell-mediated colitis, whereas TCRβδ(-/-) mice were resistant to the disease. Importantly, cotransfer of IL-17(+) but not of IL-17(-) γδ T c ...[more]