Ontology highlight
ABSTRACT:
SUBMITTER: Page A
PROVIDER: S-EPMC3201046 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Page Abigail A Clayden Jonathan J
Beilstein journal of organic chemistry 20110926
Diaryl ethers carrying carbamoyloxymethyl groups may be desymmetrised enantio- and diastereoselectively by the use of the sec-BuLi-(-)-sparteine complex in diethyl ether. Enantioselective deprotonation of one of the two benzylic positions leads to atropisomeric products with ca. 80:20 e.r.; an electrophilic quench typically provides functionalised atropisomeric diastereoisomers in up to 97:3 d.r. ...[more]