Ontology highlight
ABSTRACT:
SUBMITTER: Coppede F
PROVIDER: S-EPMC3201689 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
TheScientificWorldJournal 20111017
Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND), is an adult onset neurodegenerative disorder characterised by the degeneration of cortical and spinal cord motor neurons, resulting in progressive muscular weakness and death. Increasing evidence supports mitochondrial dysfunction and oxidative DNA damage in ALS motor neurons. Several DNA repair enzymes are activated following DNA damage to restore genome integrity, and impairments in DNA repair capabilities could con ...[more]