Ontology highlight
ABSTRACT:
SUBMITTER: Hall MD
PROVIDER: S-EPMC3201829 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Hall Matthew D MD Brimacombe Kyle R KR Varonka Matthew S MS Pluchino Kristen M KM Monda Julie K JK Li Jiayang J Walsh Martin J MJ Boxer Matthew B MB Warren Timothy H TH Fales Henry M HM Gottesman Michael M MM
Journal of medicinal chemistry 20110801 16
Cancer multidrug resistance (MDR) mediated by ATP-binding cassette (ABC) transporters presents a significant unresolved clinical challenge. One strategy to resolve MDR is to develop compounds that selectively kill cells overexpressing the efflux transporter P-glycoprotein (MDR1, P-gp, ABCB1). We have previously reported structure-activity studies based around the lead compound NSC73306 (1, 1-isatin-4-(4'-methoxyphenyl)-3-thiosemicarbazone, 4.3-fold selective). Here we sought to extend this work ...[more]