Ontology highlight
ABSTRACT:
SUBMITTER: Guichard C
PROVIDER: S-EPMC3201874 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Guichard Cécile C Ivanyi-Nagy Roland R Sharma Kamal Kant KK Gabus Caroline C Marc Daniel D Mély Yves Y Darlix Jean-Luc JL
Nucleic acids research 20110707 19
Prion diseases are unique neurodegenerative illnesses associated with the conversion of the cellular prion protein (PrP(C)) into the aggregated misfolded scrapie isoform, named PrP(Sc). Recent studies on the physiological role of PrP(C) revealed that this protein has probably multiple functions, notably in cell-cell adhesion and signal transduction, and in assisting nucleic acid folding. In fact, in vitro findings indicated that the human PrP (huPrP) possesses nucleic acid binding and annealing ...[more]