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Association of new loci identified in European genome-wide association studies with susceptibility to type 2 diabetes in the Japanese.


ABSTRACT: BACKGROUND: Several novel susceptibility loci for type 2 diabetes have been identified through genome-wide association studies (GWAS) for type 2 diabetes or quantitative traits related to glucose metabolism in European populations. To investigate the association of the 13 new European GWAS-derived susceptibility loci with type 2 diabetes in the Japanese population, we conducted a replication study using 3 independent Japanese case-control studies. METHODOLOGY/PRINCIPAL FINDINGS: We examined the association of single nucleotide polymorphisms (SNPs) within 13 loci (MTNR1B, GCK, IRS1, PROX1, BCL11A, ZBED3, KLF14, TP53INP1, KCNQ1, CENTD2, HMGA2, ZFAND6 and PRC1) with type 2 diabetes using 4,964 participants (2,839 cases and 2,125 controls) from 3 independent Japanese samples. The association of each SNP with type 2 diabetes was analyzed by logistic regression analysis. Further, we performed combined meta-analyses for the 3 studies and previously performed Japanese GWAS data (4,470 cases vs. 3,071 controls). The meta-analysis revealed that rs2943641 in the IRS1 locus was significantly associated with type 2 diabetes, (P = 0.0034, OR = 1.15 95% confidence interval; 1.05-1.26) and 3 SNPs, rs10930963 in the MTNR1B locus, rs972283 in the KLF14 locus, and rs231362 in the KCNQ1 locus, had nominal association with type 2 diabetes in the present Japanese samples (P<0.05). CONCLUSIONS: These results indicate that IRS1 locus may be common locus for type 2 diabetes across different ethnicities.

SUBMITTER: Ohshige T 

PROVIDER: S-EPMC3202571 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature

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Association of new loci identified in European genome-wide association studies with susceptibility to type 2 diabetes in the Japanese.

Ohshige Toshihiko T   Iwata Minoru M   Omori Shintaro S   Tanaka Yasushi Y   Hirose Hiroshi H   Kaku Kohei K   Maegawa Hiroshi H   Watada Hirotaka H   Kashiwagi Atsunori A   Kawamori Ryuzo R   Tobe Kazuyuki K   Kadowaki Takashi T   Nakamura Yusuke Y   Maeda Shiro S  

PloS one 20111026 10


<h4>Background</h4>Several novel susceptibility loci for type 2 diabetes have been identified through genome-wide association studies (GWAS) for type 2 diabetes or quantitative traits related to glucose metabolism in European populations. To investigate the association of the 13 new European GWAS-derived susceptibility loci with type 2 diabetes in the Japanese population, we conducted a replication study using 3 independent Japanese case-control studies.<h4>Methodology/principal findings</h4>We  ...[more]

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