Replication of breast cancer GWAS susceptibility loci in the Women's Health Initiative African American SHARe Study.

ABSTRACT:

Background

Genome-wide association studies (GWAS) have identified loci associated with risk of breast cancer. These studies have primarily been conducted in populations of European descent. To fully understand the impact of these loci, it is important to study groups with other genetic ancestries, including African American women.

Methods

We examined 22 single-nucleotide polymorphisms (SNP), previously identified in GWAS of breast cancer risk in European and Asian descent women (index SNPs), and SNPs in the surrounding regions in a study of 7,800 African American women (including 316 women with incident invasive breast cancer) from the Women's Health Initiative SNP Health Association Resource.

Results

Two index SNPs were associated with breast cancer: rs3803662 at 16q

SUBMITTER: Hutter CM 

PROVIDER: S-EPMC3202611 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature