Ontology highlight
ABSTRACT:
SUBMITTER: Feng H
PROVIDER: S-EPMC3202973 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Feng Hong H Guo Ling L Wang Dan D Gao Haiqing H Hou Guihua G Zheng Zhong Z Ai Junting J Foreman Oded O Daugherty Alan A Li Xiang-An XA
Arteriosclerosis, thrombosis, and vascular biology 20111101 11
<h4>Objective</h4>Scavenger receptor BI (SR-BI) is a high-density lipoprotein (HDL) receptor. Recent studies revealed that SR-BI protects against sepsis via modulating innate immunity. However, its role in adaptive immunity is unclear.<h4>Methods and results</h4>SR-BI-null mice exhibited impaired lymphocyte homeostasis as shown by splenomegaly and imbalanced expansion of T and B lymphocytes in the spleens. Importantly, the activated T and B lymphocytes were increased 3- to 4-fold, indicating a h ...[more]