Ontology highlight
ABSTRACT:
SUBMITTER: Cunninghame Graham DS
PROVIDER: S-EPMC3203198 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Cunninghame Graham Deborah S DS Morris David L DL Bhangale Tushar R TR Criswell Lindsey A LA Syvänen Ann-Christine AC Rönnblom Lars L Behrens Timothy W TW Graham Robert R RR Vyse Timothy J TJ
PLoS genetics 20111027 10
Systemic lupus erythematosus (SLE) is a complex trait characterised by the production of a range of auto-antibodies and a diverse set of clinical phenotypes. Currently, ~8% of the genetic contribution to SLE in Europeans is known, following publication of several moderate-sized genome-wide (GW) association studies, which identified loci with a strong effect (OR>1.3). In order to identify additional genes contributing to SLE susceptibility, we conducted a replication study in a UK dataset (870 ca ...[more]