Ivy/neurogliaform interneurons coordinate activity in the neurogenic niche.
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ABSTRACT:
SUBMITTER: Markwardt SJ
PROVIDER: S-EPMC3203322 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Publications
Ivy/neurogliaform interneurons coordinate activity in the neurogenic niche.
Markwardt Sean J SJ Dieni Cristina V CV Wadiche Jacques I JI Wadiche Jacques I JI Overstreet-Wadiche Linda L
Nature neuroscience 20111009 11
Depolarization by the neurotransmitter GABA regulates adult neurogenesis. We found interneurons of the neurogliaform cell family to be a primary source of GABA for newborn neurons in mouse dentate gyrus. GABAergic depolarization occurred in concert with reduced synaptic inhibition of mature neurons, suggesting that the local circuitry coordinates the activation of new and pre-existing cells. ...[more]
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