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Amygdala lesions selectively impair familiarity in recognition memory.

ABSTRACT: A major controversy in the study of memory concerns whether there are distinct medial temporal lobe (MTL) substrates of recollection and familiarity. Studies using receiver operating characteristics analyses of recognition memory indicate that the hippocampus is essential for recollection, but not for familiarity. We found the converse pattern in the amygdala, wherein damage impaired familiarity while sparing recollection. Combined with previous findings, these results dissociate recollection and familiarity by selective MTL damage.

SUBMITTER: Farovik A

PROVIDER: S-EPMC3203336 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature

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Amygdala lesions selectively impair familiarity in recognition memory.

Farovik Anja A Place Ryan James RJ Miller Danielle Renée DR Eichenbaum Howard H

Nature neuroscience 20110925 11

A major controversy in the study of memory concerns whether there are distinct medial temporal lobe (MTL) substrates of recollection and familiarity. Studies using receiver operating characteristics analyses of recognition memory indicate that the hippocampus is essential for recollection, but not for familiarity. We found the converse pattern in the amygdala, wherein damage impaired familiarity while sparing recollection. Combined with previous findings, these results dissociate recollection an ...[more]

PMID: 21946327

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