Sleep and waking modulate spine turnover in the adolescent mouse cortex.
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ABSTRACT:
SUBMITTER: Maret S
PROVIDER: S-EPMC3203346 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Publications
Sleep and waking modulate spine turnover in the adolescent mouse cortex.
Maret Stephanie S Faraguna Ugo U Nelson Aaron B AB Cirelli Chiara C Tononi Giulio G
Nature neuroscience 20111009 11
Cortical development involves synaptic formation and elimination. Although synaptogenesis predominates in the early stages and pruning in the later stages, the two processes are thought to happen concurrently. In adults, synaptic strength is modulated by behavioral state, and we asked whether synaptic remodeling may be affected by sleep and waking states. Using two-photon microscopy in adolescent mice, we found that waking results in a net increase in cortical spines, whereas sleep is associated ...[more]
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