Loss of zebrafish lgi1b leads to hydrocephalus and sensitization to pentylenetetrazol induced seizure-like behavior.
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ABSTRACT:
SUBMITTER: Teng Y
PROVIDER: S-EPMC3203530 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Publications
Loss of zebrafish lgi1b leads to hydrocephalus and sensitization to pentylenetetrazol induced seizure-like behavior.
Teng Yong Y Xie Xiayang X Walker Steven S Saxena Meera M Kozlowski David J DJ Mumm Jeff S JS Cowell John K JK
PloS one 20110916 9
Mutations in the LGI1 gene predispose to a hereditary epilepsy syndrome and is the first gene associated with this disease which does not encode an ion channel protein. In zebrafish, there are two paralogs of the LGI1 gene, lgi1a and lgi1b. Knockdown of lgi1a results in a seizure-like hyperactivity phenotype with associated developmental abnormalities characterized by cellular loss in the eyes and brain. We have now generated knockdown morphants for the lgi1b gene which also show developmental a ...[more]
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