Ontology highlight
ABSTRACT:
SUBMITTER: Trejbalova K
PROVIDER: S-EPMC3203578 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Trejbalová Katerina K Blazková Jana J Matousková Magda M Kucerová Dana D Pecnová Lubomíra L Vernerová Zdenka Z Herácek Jirí J Hirsch Ivan I Hejnar Jirí J
Nucleic acids research 20110719 20
Syncytin-1 and -2, human fusogenic glycoproteins encoded by the env genes of the endogenous retroviral loci ERVWE1 and ERVFRDE1, respectively, contribute to the differentiation of multinucleated syncytiotrophoblast in chorionic villi. In non-trophoblastic cells, however, the expression of syncytins has to be suppressed to avoid potential pathogenic effects. We studied the epigenetic suppression of ERVWE1 and ERVFRDE1 5'-long terminal repeats by DNA methylation and chromatin modifications. Immuno ...[more]