Ontology highlight
ABSTRACT:
SUBMITTER: Cal-Bakowska M
PROVIDER: S-EPMC3203583 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Cal-Bakowska Magdalena M Litwin Ireneusz I Bocer Tomasz T Wysocki Robert R Dziadkowiec Dorota D
Nucleic acids research 20110715 20
The Saccharomyces cerevisiae Uls1 belongs to the Swi2-Snf2 family of DNA-dependent ATPases and a new protein family of SUMO-targeted ubiquitin ligases. Here, we examine a physiological role of Uls1 and report for the first time its involvement in response to replication stress. We found that deletion of ULS1 in cells lacking RAD52 caused a synthetic growth defect accompanied by prolonged S phase and aberrant cell morphology. uls1Δ also progressed slower through S phase upon MMS treatment and too ...[more]