Ontology highlight
ABSTRACT:
SUBMITTER: Feige E
PROVIDER: S-EPMC3203758 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Feige Erez E Yokoyama Satoru S Levy Carmit C Khaled Mehdi M Igras Vivien V Lin Richard J RJ Lee Stephen S Widlund Hans R HR Granter Scott R SR Kung Andrew L AL Fisher David E DE
Proceedings of the National Academy of Sciences of the United States of America 20110926 43
Microphthalmia-associated transcription factor (MITF) regulates normal melanocyte development and is also a lineage-selective oncogene implicated in melanoma and clear-cell sarcoma (i.e., melanoma of soft parts). We have observed that MITF expression is potently reduced under hypoxic conditions in primary melanocytes and melanoma and clear cell sarcoma cells through hypoxia inducible factor 1 (HIF1)-mediated induction of the transcriptional repressor differentially expressed in chondrocytes prot ...[more]