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Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma.


ABSTRACT: Squamous cell carcinomas (SCCs) are one of the most frequent forms of human malignancy, but, other than TP53 mutations, few causative somatic aberrations have been identified. We identified NOTCH1 or NOTCH2 mutations in ~75% of cutaneous SCCs and in a lesser fraction of lung SCCs, defining a spectrum for the most prevalent tumor suppressor specific to these epithelial malignancies. Notch receptors normally transduce signals in response to ligands on neighboring cells, regulating metazoan lineage selection and developmental patterning. Our findings therefore illustrate a central role for disruption of microenvironmental communication in cancer progression. NOTCH aberrations include frameshift and nonsense mutations leading to receptor truncations as well as point substitutions in key functional domains that abrogate signaling in cell-based assays. Oncogenic gain-of-function mutations in NOTCH1 commonly occur in human T-cell lymphoblastic leukemia/lymphoma and B-cell chronic lymphocytic leukemia. The bifunctional role of Notch in human cancer thus emphasizes the context dependency of signaling outcomes and suggests that targeted inhibition of the Notch pathway may induce squamous epithelial malignancies.

SUBMITTER: Wang NJ 

PROVIDER: S-EPMC3203814 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature

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Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma.

Wang Nicholas J NJ   Sanborn Zachary Z   Arnett Kelly L KL   Bayston Laura J LJ   Liao Wilson W   Proby Charlotte M CM   Leigh Irene M IM   Collisson Eric A EA   Gordon Patricia B PB   Jakkula Lakshmi L   Pennypacker Sally S   Zou Yong Y   Sharma Mimansa M   North Jeffrey P JP   Vemula Swapna S SS   Mauro Theodora M TM   Neuhaus Isaac M IM   Leboit Philip E PE   Hur Joe S JS   Park Kyunghee K   Huh Nam N   Kwok Pui-Yan PY   Arron Sarah T ST   Massion Pierre P PP   Bale Allen E AE   Haussler David D   Cleaver James E JE   Gray Joe W JW   Spellman Paul T PT   South Andrew P AP   Aster Jon C JC   Blacklow Stephen C SC   Cho Raymond J RJ  

Proceedings of the National Academy of Sciences of the United States of America 20111017 43


Squamous cell carcinomas (SCCs) are one of the most frequent forms of human malignancy, but, other than TP53 mutations, few causative somatic aberrations have been identified. We identified NOTCH1 or NOTCH2 mutations in ~75% of cutaneous SCCs and in a lesser fraction of lung SCCs, defining a spectrum for the most prevalent tumor suppressor specific to these epithelial malignancies. Notch receptors normally transduce signals in response to ligands on neighboring cells, regulating metazoan lineage  ...[more]

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