Ontology highlight
ABSTRACT:
SUBMITTER: Koh CY
PROVIDER: S-EPMC3203879 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Koh Cho Yeow CY Kumar Sundramurthy S Kazimirova Maria M Nuttall Patricia A PA Radhakrishnan Uvaraj P UP Kim Seongcheol S Jagadeeswaran Pudur P Imamura Takayuki T Mizuguchi Jun J Iwanaga Sadaaki S Swaminathan Kunchithapadam K Kini R Manjunatha RM
PloS one 20111028 10
The inhibition of thrombin is one of the important treatments of pathological blood clot formation. Variegin, isolated from the tropical bont tick, is a novel molecule exhibiting a unique 'two-modes' inhibitory property on thrombin active site (competitive before cleavage, noncompetitive after cleavage). For the better understanding of its function, we have determined the crystal structure of the human α-thrombin:synthetic-variegin complex at 2.4 Å resolution. The structure reveals a new mechani ...[more]