Ontology highlight
ABSTRACT:
SUBMITTER: Tassi E
PROVIDER: S-EPMC3204016 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Tassi Elena E McDonnell Kevin K Gibby Krissa A KA Tilan Jason U JU Kim Sung E SE Kodack David P DP Schmidt Marcel O MO Sharif Ghada M GM Wilcox Christopher S CS Welch William J WJ Gallicano G Ian GI Johnson Michael D MD Riegel Anna T AT Wellstein Anton A
The American journal of pathology 20110921 5
Fibroblast growth factors (FGFs) participate in embryonic development, in maintenance of tissue homeostasis in the adult, and in various diseases. FGF-binding proteins (FGFBP) are secreted proteins that chaperone FGFs stored in the extracellular matrix to their receptor, and can thus modulate FGF signaling. FGFBP1 (alias BP1, FGF-BP1, or HBp17) expression is required for embryonic survival, can modulate FGF-dependent vascular permeability in embryos, and is an angiogenic switch in human cancers. ...[more]