Ontology highlight
ABSTRACT:
SUBMITTER: Zonouzi M
PROVIDER: S-EPMC3204222 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Zonouzi Marzieh M Renzi Massimiliano M Farrant Mark M Cull-Candy Stuart G SG
Nature neuroscience 20111009 11
Oligodendrocyte precursor cells (OPCs), a major glial cell type that gives rise to myelinating oligodendrocytes in the CNS, express calcium-permeable AMPA receptors (CP-AMPARs). Although CP-AMPARs are important for OPC proliferation and neuron-glia signaling, they render OPCs susceptible to ischemic damage in early development. We identified factors controlling the dynamic regulation of AMPAR subtypes in OPCs from rat optic nerve and mouse cerebellar cortex. We found that activation of group 1 m ...[more]