Ontology highlight
ABSTRACT:
SUBMITTER: Miller TW
PROVIDER: S-EPMC3204388 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Miller Todd W TW Balko Justin M JM Fox Emily M EM Ghazoui Zara Z Dunbier Anita A Anderson Helen H Dowsett Mitch M Jiang Aixiang A Smith R Adam RA Maira Sauveur-Michel SM Manning H Charles HC González-Angulo Ana M AM Mills Gordon B GB Higham Catherine C Chanthaphaychith Siprachanh S Kuba Maria G MG Miller William R WR Shyr Yu Y Arteaga Carlos L CL
Cancer discovery 20110720 4
Most estrogen receptor α (ER)-positive breast cancers initially respond to antiestrogens, but many eventually become estrogen-independent and recur. We identified an estrogen-independent role for ER and the CDK4/Rb/E2F transcriptional axis in the hormone-independent growth of breast cancer cells. ER downregulation with fulvestrant or small interfering RNA (siRNA) inhibited estrogen-independent growth. Chromatin immunoprecipitation identified ER genomic binding activity in estrogen-deprived cells ...[more]