Ontology highlight
ABSTRACT:
SUBMITTER: Steinbicker AU
PROVIDER: S-EPMC3204739 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Steinbicker Andrea U AU Bartnikas Thomas B TB Lohmeyer Lisa K LK Leyton Patricio P Mayeur Claire C Kao Sonya M SM Pappas Alexandra E AE Peterson Randall T RT Bloch Donald B DB Yu Paul B PB Fleming Mark D MD Bloch Kenneth D KD
Blood 20110812 15
Bone morphogenetic protein (BMP) signaling induces hepatic expression of the peptide hormone hepcidin. Hepcidin reduces serum iron levels by promoting degradation of the iron exporter ferroportin. A relative deficiency of hepcidin underlies the pathophysiology of many of the genetically distinct iron overload disorders, collectively termed hereditary hemochromatosis. Conversely, chronic inflammatory conditions and neoplastic diseases can induce high hepcidin levels, leading to impaired mobilizat ...[more]