Ontology highlight
ABSTRACT:
SUBMITTER: Wickliffe KE
PROVIDER: S-EPMC3205209 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Trends in cell biology 20111004 11
Modification of proteins with ubiquitin chains is an essential regulatory event in cell cycle control. Differences in the connectivity of ubiquitin chains are believed to result in distinct functional consequences for the modified proteins. Among eight possible homogenous chain types, canonical Lys48-linked ubiquitin chains have long been recognized to drive the proteasomal degradation of cell cycle regulators, and Lys48 is the only essential lysine residue of ubiquitin in yeast. It thus came as ...[more]