Ontology highlight
ABSTRACT:
SUBMITTER: Zhong J
PROVIDER: S-EPMC3205450 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Zhong Jun J Chaerkady Raghothama R Kandasamy Kumaran K Gucek Marjan M Cole Robert N RN Pandey Akhilesh A
Journal of proteomics 20101113 3
Signal transduction pathways are tightly controlled by positive and negative regulators. We have previously identified Odin (also known as ankyrin repeat and sterile alpha motif domain-containing 1A; gene symbol ANKS1A) as a negative regulator of growth factor signaling; however, the mechanisms through which Odin regulates these pathways remain to be elucidated. To determine how Odin negatively regulates growth factor signaling, we undertook a proteomic approach to systematically identify protei ...[more]