Ontology highlight
ABSTRACT:
SUBMITTER: Drew K
PROVIDER: S-EPMC3205581 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Drew Kevin K Winters Patrick P Butterfoss Glenn L GL Berstis Viktors V Uplinger Keith K Armstrong Jonathan J Riffle Michael M Schweighofer Erik E Bovermann Bill B Goodlett David R DR Davis Trisha N TN Shasha Dennis D Malmström Lars L Bonneau Richard R
Genome research 20110808 11
The incompleteness of proteome structure and function annotation is a critical problem for biologists and, in particular, severely limits interpretation of high-throughput and next-generation experiments. We have developed a proteome annotation pipeline based on structure prediction, where function and structure annotations are generated using an integration of sequence comparison, fold recognition, and grid-computing-enabled de novo structure prediction. We predict protein domain boundaries and ...[more]