Acute decline in serum sclerostin in response to PTH infusion in healthy men.

ABSTRACT:

Context

Animal models suggest that the osteoblast-stimulating actions of PTH are mediated by acute suppression of sclerostin, an inhibitor of the anabolic Wnt pathway. The immediate physiological changes in serum sclerostin in response to PTH infusion have not been reported in human studies.

Objective

We sought to determine the acute physiological effects of PTH infusion on serum sclerostin and bone turnover markers in healthy adult men.

Design, setting, and participants

Fifty-three healthy adult men underwent an 18-h iv infusion of human PTH(1-34) at a dose of 0.55 U/kg · h.

Outcomes

Serum levels of ionized calcium, sclerostin, and markers of bone formation (osteocalcin and amino-terminal propeptide of type I procollagen) and bone resorption (C-telopeptide and

SUBMITTER: Yu EW 

PROVIDER: S-EPMC3205893 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature