Convergent pathogenic pathways in Alzheimer's and Huntington's diseases: shared targets for drug development.
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ABSTRACT:
SUBMITTER: Ehrnhoefer DE
PROVIDER: S-EPMC3206090 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Publications
Convergent pathogenic pathways in Alzheimer's and Huntington's diseases: shared targets for drug development.
Ehrnhoefer Dagmar E DE Wong Bibiana K Y BK Hayden Michael R MR
Nature reviews. Drug discovery 20111021 11
Neurodegenerative diseases, exemplified by Alzheimer's disease and Huntington's disease, are characterized by progressive neuropsychiatric dysfunction and loss of specific neuronal subtypes. Although there are differences in the exact sites of pathology, and the clinical profiles of these two conditions only partially overlap, considerable similarities in disease mechanisms and pathogenic pathways can be observed. These shared mechanisms raise the possibility of exploiting common therapeutic tar ...[more]
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