Calcium-dependent mitochondrial extrusion in ciliated protozoa.
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ABSTRACT:
SUBMITTER: Bisharyan Y
PROVIDER: S-EPMC3206207 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Publications
Calcium-dependent mitochondrial extrusion in ciliated protozoa.
Bisharyan Yelena Y Clark Theodore G TG
Mitochondrion 20110811 6
Here we demonstrate that ciliated protozoa can jettison mitochondria as intact organelles, releasing their contents to the extracellular space either in a soluble form, or in association with membrane vesicles at the cell periphery. The response is triggered by lateral clustering of GPI-anchored surface antigens, or by heat shock. In the first instance, extrusion is accompanied by elevated levels of intracellular calcium and is inhibited by Verapamil and BAPTA-AM arguing strongly for the involve ...[more]
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