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Antibody responses and cross protection against lethal influenza A viruses differ between the sexes in C57BL/6 mice.

ABSTRACT: A mouse model was used to determine if protective immunity to influenza A virus infection differs between the sexes. The median lethal dose of H1N1 or H3N2 was lower for naïve females than males. After a sublethal, primary infection with H1N1 or H3N2, females and males showed a similar transient morbidity, but females generated more neutralizing and total anti-influenza A virus antibodies. Immunized males and females showed similar protection against secondary challenge with a homologous virus, but males experienced greater morbidity and had higher lung viral titers after infection with a lethal dose of heterologous virus. Females develop stronger humoral immune responses and greater cross protection against heterosubtypic virus challenge.

SUBMITTER: Lorenzo ME

PROVIDER: S-EPMC3206291 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature

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Antibody responses and cross protection against lethal influenza A viruses differ between the sexes in C57BL/6 mice.

Lorenzo Maria E ME Hodgson Andrea A Robinson Dionne P DP Kaplan Jenifer B JB Pekosz Andrew A Klein Sabra L SL

Vaccine 20111006 49

A mouse model was used to determine if protective immunity to influenza A virus infection differs between the sexes. The median lethal dose of H1N1 or H3N2 was lower for naïve females than males. After a sublethal, primary infection with H1N1 or H3N2, females and males showed a similar transient morbidity, but females generated more neutralizing and total anti-influenza A virus antibodies. Immunized males and females showed similar protection against secondary challenge with a homologous virus, ...[more]

PMID: 21983155

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