Ontology highlight
ABSTRACT:
SUBMITTER: Beaulieu JM
PROVIDER: S-EPMC3206544 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Frontiers in molecular neuroscience 20111101
Brain dopamine receptors have been preferred targets for numerous pharmacological compounds developed for the treatment of various neuropsychiatric disorders. Recent discovery that D2 dopamine receptors, in addition to cAMP pathways, can engage also in Akt/GSK3 signaling cascade provided a new framework to understand intracellular signaling mechanisms involved in dopamine-related behaviors and pathologies. Here we review a recent progress in understanding the role of Akt, GSK3, and related signa ...[more]