Ontology highlight
ABSTRACT:
SUBMITTER: Badran AH
PROVIDER: S-EPMC3206592 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Badran Ahmed H AH Furman Jennifer L JL Ma Andrew S AS Comi Troy J TJ Porter Jason R JR Ghosh Indraneel I
Analytical chemistry 20110823 18
Epigenetic modifications play an essential role in the regulation of gene expression and ultimately cell fate. Methylation of cytosine at CpG dinucleotides (mCpG) is an important epigenetic mark that has been correlated with cancer when present at promoter sites of tumor suppressor genes. To develop a rapid methodology for the direct assessment of global levels of DNA methylation, we first interrogated the methyl-CpG binding domains (MBDs), the Kaiso family of Cys(2)-His(2) zinc fingers, and an ...[more]