PDZ binding of TARP?-8 controls synaptic transmission but not synaptic plasticity.
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ABSTRACT:
SUBMITTER: Sumioka A
PROVIDER: S-EPMC3206644 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Publications
PDZ binding of TARPγ-8 controls synaptic transmission but not synaptic plasticity.
Sumioka Akio A Brown Travis E TE Kato Akihiko S AS Bredt David S DS Kauer Julie A JA Tomita Susumu S
Nature neuroscience 20111016 11
The reduction in synaptic transmission and plasticity in mice lacking the hippocampus-enriched AMPA receptor (AMPAR) auxiliary subunit TARPγ-8 could be a result of a reduction in AMPAR expression or of the direct action of γ-8. We generated TARPγ-8Δ4 knock-in mice lacking the C-terminal PDZ ligand. We found that synaptic transmission and AMPARs were reduced in the mutant mice, but extrasynaptic AMPAR expression and long-term potentiation (LTP) were unaltered. Our findings suggest that there are ...[more]
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