Reduction of thyroid nodule volume by levothyroxine and iodine alone and in combination: a randomized, placebo-controlled trial.

ABSTRACT:

Context

Nodular goiter is common worldwide, but there is still debate over the medical treatment.

Objective

The objective of the study was the measurement of the effect of a treatment with (nonsuppressive) T(4), iodine, or a combination of both compared with placebo on volume of thyroid nodules and thyroid.

Design

This was a multicenter, randomized, double-blind trial in patients with nodular goiter in Germany [LISA (Levothyroxin und Iodid in der Strumatherapie Als Mono-oder Kombinationstherapie) trial].

Setting

The study was conducted in outpatient clinics in university hospitals and regional hospitals and private practices.

Participants

One thousand twenty-four consecutively screened and centrally randomized euthyroid patients aged 18-65 yr with one or

SUBMITTER: Grussendorf M 

PROVIDER: S-EPMC3206705 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature