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Three-dimensional impedance map analysis of rabbit liver.

ABSTRACT: Three-dimensional impedance maps (3DZMs) are computational models of acoustic impedance of tissue constructed from histology images. 3DZMs can be analyzed to estimate model-based quantitative ultrasound parameters such as effective scatterer diameter (ESD). In this study, 3DZMs were constructed from normal and fatty rabbit livers. Estimates of ESD were made using the fluid-filled sphere scattering model. Weighting toward smaller scatterer sizes produced ESD estimates of 7.5 ?±? 1.3 and 7.0? ± ?0.3 ?m for normal and fatty liver, respectively, approximately the size of a liver cell nucleus. This suggests the nucleus could be a primary source of scattering in liver.

SUBMITTER: Pawlicki AD

PROVIDER: S-EPMC3206901 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature

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Three-dimensional impedance map analysis of rabbit liver.

Pawlicki Alexander D AD Dapore Alexander J AJ Sarwate Sandhya S O'Brien William D WD

The Journal of the Acoustical Society of America 20111101 5

Three-dimensional impedance maps (3DZMs) are computational models of acoustic impedance of tissue constructed from histology images. 3DZMs can be analyzed to estimate model-based quantitative ultrasound parameters such as effective scatterer diameter (ESD). In this study, 3DZMs were constructed from normal and fatty rabbit livers. Estimates of ESD were made using the fluid-filled sphere scattering model. Weighting toward smaller scatterer sizes produced ESD estimates of 7.5 ± 1.3 and 7.0 ± 0 ...[more]

PMID: 22088037

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