Acetylation regulates monopolar attachment at multiple levels during meiosis I in fission yeast.
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ABSTRACT:
SUBMITTER: Kagami A
PROVIDER: S-EPMC3207105 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Publications
Acetylation regulates monopolar attachment at multiple levels during meiosis I in fission yeast.
Kagami Ayano A Sakuno Takeshi T Yamagishi Yuya Y Ishiguro Tadashi T Tsukahara Tatsuya T Shirahige Katsuhiko K Tanaka Koichi K Watanabe Yoshinori Y
EMBO reports 20111028 11
In fission yeast, meiotic mono-orientation of sister kinetochores is established by cohesion at the core centromere, which is established by a meiotic cohesin complex and the kinetochore protein Moa1. The cohesin subunit Psm3 is acetylated by Eso1 and deacetylated by Clr6. We show that in meiosis, Eso1 is required for establishing core centromere cohesion during S phase, whereas Moa1 is required for maintaining this cohesion after S phase. The clr6-1 mutation suppresses the mono-orientation defe ...[more]
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