Ontology highlight
ABSTRACT:
SUBMITTER: Nogee LM
PROVIDER: S-EPMC3207222 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Pediatric allergy, immunology, and pulmonology 20100301 1
Specific genetic causes for children's interstitial lung disease (chILD) have been identified within the past decade. These include deletions of or mutations in genes encoding proteins important in surfactant production and function (SP-B, SP-C, and ABCA3), surfactant catabolism (GM-CSF receptor), as well as transcription factors important for surfactant production (TTF1) or lung development (Fox F1), with heterozygous deletions or loss-of-function mutations of the latter resulting in alveolar c ...[more]