Ontology highlight
ABSTRACT:
SUBMITTER: Saez-Rodriguez J
PROVIDER: S-EPMC3207250 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Saez-Rodriguez Julio J Alexopoulos Leonidas G LG Zhang Mingsheng M Morris Melody K MK Lauffenburger Douglas A DA Sorger Peter K PK
Cancer research 20110708 16
Substantial effort in recent years has been devoted to constructing and analyzing large-scale gene and protein networks on the basis of "omic" data and literature mining. These interaction graphs provide valuable insight into the topologies of complex biological networks but are rarely context specific and cannot be used to predict the responses of cell signaling proteins to specific ligands or drugs. Conversely, traditional approaches to analyzing cell signaling are narrow in scope and cannot e ...[more]