Ensuring congruency in multiscale modeling: towards linking agent based and continuum biomechanical models of arterial adaptation.

ABSTRACT: There is a need to develop multiscale models of vascular adaptations to understand tissue-level manifestations of cellular level mechanisms. Continuum-based biomechanical models are well suited for relating blood pressures and flows to stress-mediated changes in geometry and properties, but less so for describing underlying mechanobiological processes. Discrete stochastic agent-based models are well suited for representing biological processes at a cellular level, but not for describing tissue-level mechanical changes. We present here a conceptually new approach to facilitate the coupling of continuum and agent-based models. Because of ubiquitous limitations in both the tissue- and cell-level data from which one derives constitutive relations for continuum models and rule-sets for agent-ba

SUBMITTER: Hayenga HN 

PROVIDER: S-EPMC3207323 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature