Ontology highlight
ABSTRACT:
SUBMITTER: Wada S
PROVIDER: S-EPMC3207415 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Wada Shogo S Kato Yoshio Y Okutsu Mitsuharu M Miyaki Shigeru S Suzuki Katsuhiko K Yan Zhen Z Schiaffino Stefano S Asahara Hiroshi H Ushida Takashi T Akimoto Takayuki T
The Journal of biological chemistry 20110918 44
Muscle atrophy is caused by accelerated protein degradation and occurs in many pathological states. Two muscle-specific ubiquitin ligases, MAFbx/atrogin-1 and muscle RING-finger 1 (MuRF1), are prominently induced during muscle atrophy and mediate atrophy-associated protein degradation. Blocking the expression of these two ubiquitin ligases provides protection against muscle atrophy. Here we report that miR-23a suppresses the translation of both MAFbx/atrogin-1 and MuRF1 in a 3'-UTR-dependent man ...[more]