Ontology highlight
ABSTRACT:
SUBMITTER: Krishna Kumar K
PROVIDER: S-EPMC3207429 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Krishna Kumar Kaavya K Jacques David A DA Pishchany Gleb G Caradoc-Davies Tom T Spirig Thomas T Malmirchegini G Reza GR Langley David B DB Dickson Claire F CF Mackay Joel P JP Clubb Robert T RT Skaar Eric P EP Guss J Mitchell JM Gell David A DA
The Journal of biological chemistry 20110914 44
Pathogens must steal iron from their hosts to establish infection. In mammals, hemoglobin (Hb) represents the largest reservoir of iron, and pathogens express Hb-binding proteins to access this source. Here, we show how one of the commonest and most significant human pathogens, Staphylococcus aureus, captures Hb as the first step of an iron-scavenging pathway. The x-ray crystal structure of Hb bound to a domain from the Isd (iron-regulated surface determinant) protein, IsdH, is the first structu ...[more]