Ontology highlight
ABSTRACT:
SUBMITTER: Stoll EA
PROVIDER: S-EPMC3207440 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Stoll Elizabeth A EA Cheung Willy W Mikheev Andrei M AM Sweet Ian R IR Bielas Jason H JH Zhang Jing J Rostomily Robert C RC Horner Philip J PJ
The Journal of biological chemistry 20110907 44
Although neurogenesis occurs in discrete areas of the adult mammalian brain, neural progenitor cells (NPCs) produce fewer new neurons with age. To characterize the molecular changes that occur during aging, we performed a proteomic comparison between primary-cultured NPCs from the young adult and aged mouse forebrain. This analysis yielded changes in proteins necessary for cellular metabolism. Mitochondrial quantity and oxygen consumption rates decrease with aging, although mitochondrial DNA in ...[more]