Ontology highlight
ABSTRACT:
SUBMITTER: Paroder-Belenitsky M
PROVIDER: S-EPMC3207644 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Paroder-Belenitsky Monika M Maestas Matthew J MJ Dohán Orsolya O Nicola Juan Pablo JP Reyna-Neyra Andrea A Follenzi Antonia A Dadachova Ekaterina E Eskandari Sepehr S Amzel L Mario LM Carrasco Nancy N
Proceedings of the National Academy of Sciences of the United States of America 20111019 44
I(-) uptake in the thyroid, the first step in thyroid hormone biosynthesis, is mediated by the Na(+)/I(-) symporter (NIS) with an electrogenic 2Na(+):1I(-) stoichiometry. We have obtained mechanistic information on NIS by characterizing the congenital I(-) transport defect-causing NIS mutant G93R. This mutant is targeted to the plasma membrane but is inactive. Substitutions at position 93 show that the longer the side chain of the neutral residue at this position, the higher the K(m) for the ani ...[more]