Ontology highlight
ABSTRACT:
SUBMITTER: Seo S
PROVIDER: S-EPMC3207910 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
PLoS genetics 20111103 11
Many signaling proteins including G protein-coupled receptors localize to primary cilia, regulating cellular processes including differentiation, proliferation, organogenesis, and tumorigenesis. Bardet-Biedl Syndrome (BBS) proteins are involved in maintaining ciliary function by mediating protein trafficking to the cilia. However, the mechanisms governing ciliary trafficking by BBS proteins are not well understood. Here, we show that a novel protein, Leucine-zipper transcription factor-like 1 (L ...[more]