Ontology highlight
ABSTRACT:
SUBMITTER: Motegi F
PROVIDER: S-EPMC3208083 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Motegi Fumio F Zonies Seth S Hao Yingsong Y Cuenca Adrian A AA Griffin Erik E Seydoux Geraldine G
Nature cell biology 20111009 11
A hallmark of polarized cells is the segregation of the PAR polarity regulators into asymmetric domains at the cell cortex. Antagonistic interactions involving two conserved kinases, atypical protein kinase C (aPKC) and PAR-1, have been implicated in polarity maintenance, but the mechanisms that initiate the formation of asymmetric PAR domains are not understood. Here, we describe one pathway used by the sperm-donated centrosome to polarize the PAR proteins in Caenorhabditis elegans zygotes. Bef ...[more]