Ontology highlight
ABSTRACT:
SUBMITTER: Chaudhuri AA
PROVIDER: S-EPMC3208133 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Chaudhuri Aadel A AA So Alex Yick-Lun AY Sinha Nikita N Gibson William S J WS Taganov Konstantin D KD O'Connell Ryan M RM Baltimore David D
Journal of immunology (Baltimore, Md. : 1950) 20111014 10
MicroRNA (miR)-125b expression is modulated in macrophages in response to stimulatory cues. In this study, we report a functional role of miR-125b in macrophages. We found that miR-125b is enriched in macrophages compared with lymphoid cells and whole immune tissues. Enforced expression of miR-125b drives macrophages to adapt an activated morphology that is accompanied by increased costimulatory factor expression and elevated responsiveness to IFN-γ, whereas anti-miR-125b treatment decreases CD8 ...[more]