Modeling socio-demography to capture tuberculosis transmission dynamics in a low burden setting.

ABSTRACT: Evidence of preferential mixing through selected social routes has been suggested for the transmission of tuberculosis (TB) infection in low burden settings. A realistic modelization of these contact routes is needed to appropriately assess the impact of individually targeted control strategies, such as contact network investigation of index cases and treatment of latent TB infection (LTBI). We propose an age-structured, socio-demographic individual based model (IBM) with a realistic, time-evolving structure of preferential contacts in a population. In particular, transmission within households, schools and workplaces, together with a component of casual, distance-dependent contacts are considered. We also compared the model against two other formulations having no social structure of cont

SUBMITTER: Guzzetta G 

PROVIDER: S-EPMC3208139 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature