Association of corticotropin-releasing hormone receptor-2 genetic variants with acute bronchodilator response in asthma.

ABSTRACT: Corticotropin-releasing hormone receptor (CRHR)-2 participates in smooth muscle relaxation response and may influence acute airway bronchodilator response to short-acting beta2-agonist treatment of asthma. We aim to assess associations between genetic variants of CRHR2 and acute bronchodilator response in asthma.We investigated 28 single nucleotide polymorphisms in CRHR2 for associations with acute bronchodilator response to albuterol in 607 Caucasian asthmatic patients recruited as part of the Childhood Asthma Management Program. Replication was conducted in two Caucasian adult asthma cohorts--a cohort of 427 participants enrolled in a completed clinical trial conducted by Sepracor Inc. (Massachusetts, USA) and a cohort of 152 participants enrolled in the Clinical Trial of Low-Dose Theophylline and Montelukast conducted by the American Lung Association Asthma Clinical Research Centers.Five variants were significantly associated with acute bronchodilator response in at least one cohort (P

SUBMITTER: Poon AH 

PROVIDER: S-EPMC3208318 | biostudies-literature | 2008 May

REPOSITORIES: biostudies-literature